Iyini i-Artesunate Powder?

I-Artesunate iyisibulala-zinambuzane esisheshayo ngokumelene nePlasmodium falciparum esigabeni se-erythrocytic, esisebenza ngempumelelo ngokumelene. Ingakwazi ukulawula ngokushesha ukuhlasela kwe-malaria ngemva kokuyithatha. Isetshenziselwa ukuhlenga umalaleveva oyingozi njengohlobo lobuchopho kanye nohlobo lwe-icteric, kanye nokwelapha umalaleveva we-falciparum.

Indlela ye-artesunate yi-artemisinin. Iqala isebenza kulwelwesi lwe-vesicle yokudla, ulwelwesi olungaphezulu kanye ne-mitochondria yePlasmodium. Owesibili ulwelwesi lwenuzi kanye ne-endoplasmic reticulum. Ngaphezu kwalokho, iphinde ibe nomthelela othile ku-chromatin ku-nucleus. Ngoba lo mkhiqizo uqala ukusebenza kulwelwesi lwebhamuza lokudla, ngaleyo ndlela uvimbe ukudla okunomsoco, okubangela ukuba isilwane sikamalaleveva silambe ngokushesha ama-amino acid, senze ngokushesha amagwebu e-autophagic, futhi siqhubeke nokuphuma emzimbeni, silahlekelwe inani elikhulu le-cytoplasm futhi sife. .

Umsebenzi we-Artesunate:

I-Artesunate iyi-ejenti elwa nomalaleveva. Kuyi-hemisuccinate encibilikayo emanzini ephuma ku-dihydroartemisinin.

I-Artemisinin i-sesquiterpene lactone ehlukanisiwe ne-Artemisia annua, isitshalo esivame ukusetshenziswa e-China ukwelapha umalaleveva.

I-Artesunate kanye ne-metabolite yayo esebenzayo i-dihydroartemisinin ama-schizonticides egazi anamandla, asebenza ngokumelene nesigaba sendandatho ye-parasite.

I-Artesunate ilungele ukwelapha umalaleveva onzima, kuhlanganise nomalaleveva wobuchopho. Iphinde isebenze ngokumelene nezinhlobo ezimelana ne-mefloquine ze-P. falciparum. Ayizinzile kusisombululo esimaphakathi ngakho-ke itholakala kuphela ngemijovo njenge-artesunic acid.

Isicelo

1. Isetshenziswa emkhakheni wokudla, isiphenduke into entsha eluhlaza esetshenziswa embonini yokudla neziphuzo;
2. Kusetshenziswa emkhakheni womkhiqizo wezempilo, kuwumkhiqizo wezempilo wemvelo olawula ukulala;
3. Kusetshenziswa emkhakheni wezokwelapha, ngomphumela omuhle wokwelapha isifo sokusha kwesibindi kohlobo.

Isitoreji Esinconyiwe:
I-Artemisinin inconywa ukuthi igcinwe endaweni epholile, eyomile, evalwe emoyeni ongaphandle. Sithumela umkhiqizo esikhwameni esivalwe kabili esingavalwa kabusha. Esinye isitsha sinconywa ukuthi sivalwe emoyeni wangaphandle.