I-Fisetin Powder iyinhlanganisela yemvelo ye-flavonoid etholakala kakhulu ezithelweni nasemifino. Njenge-molecule engaba khona ye-bioactive, i-Fisetin idonse ukunaka okusabalele emphakathini wesayensi. Isakhiwo sayo samakhemikhali siqukethe amaqembu amaningi e-hydroxyl, okwenza ibe nezakhiwo ezinhle ze-antioxidant. Ucwaningo luye lwabonisa ukuthi i-Fisetin ingase yenze umsebenzi webhayoloji ngokulawula izindlela eziningi zokubonisa, ezithinta izinqubo ezifana nomjikelezo weseli kanye ne-apoptosis. Kodwa-ke, ucwaningo olwengeziwe luyadingeka nge-bioavailability kanye ne-pharmacokinetics ye-Fisetin ukuze kwembule indlela yokusebenza kwayo emzimbeni womuntu. Kodwa-ke, udaba lokuthi ukudla kwansuku zonke kwe-Fisetin kuphephile sekunakwe kakhulu. Lesi sihloko sizohlola ngokuhlelekile ukuphepha kokudla kwansuku zonke kwe-Fisetin ngemibono ehlukene.
Iyini i-Fisetin?
I-Fisetin iyinhlanganisela yemvelo ye-flavonoid, eyingxenye ye-flavonoid compounds. Itholakala ezitshalweni eziningi, njengama-apula, ama-strawberry, ulamula, futhi iye yatholakala ekudleni okufana no-anyanisi namakhukhamba. Uma sikhuluma ngamakhemikhali, i-Fisetin iyi-flavonoid enesakhiwo sezindandatho ezimbili ze-benzene kanye ne-heterocycle eyodwa, equkethe amaqembu amaningi e-hydroxyl. Lezi zakhiwo ze-hydroxyl zinikeza i-Fisetin ngezakhiwo ezinhle kakhulu ze-antioxidant.
I-Fisetin idonse ukunaka okusabalele emphakathini wesayensi ngenxa yesakhiwo sayo samakhemikhali esiyingqayizivele kanye nomsebenzi webhayoloji. Ucwaningo luye lwabonisa ukuthi i-Fisetin ingase ibe nemiphumela yokulawula ezinqubweni zebhayoloji ezifana nomjikelezo weseli kanye ne-apoptosis, kuyilapho futhi inemisebenzi ethile yebhayoloji. Ku-vivo, i-Fisetin ingase ibe nemiphumela yayo ngokulawula izindlela eziningi zokubonisa izimpawu, kodwa ucwaningo olwengeziwe mayelana nokutholakala kwayo kwe-bioavailability kanye ne-pharmacokinetics luyadingeka ukuze kwembule indlela yokusebenza kwayo emzimbeni womuntu. Sekukonke, njengenhlanganisela yemvelo, i-Fisetin inesakhiwo samakhemikhali esiyingqayizivele nomsebenzi webhayoloji, futhi indlela yayo yokusebenza emzimbeni womuntu idinga ucwaningo olwengeziwe.
Izinzuzo ze-Fisetin Powder
1. Umphumela we-antioxidant we-Fisetin
98% Fisetiniyinhlanganisela yemvelo ye-flavonoid enezakhiwo ezinhle kakhulu ze-antioxidant.
(1). Isakhiwo samakhemikhali seFisetin
I-Fisetin iyinhlanganisela ye-flavonoid yemvelo enefomula yamangqamuzana C ₁æ H ₁₀O ₆. Iqukethe izakhiwo eziningi ze-hydroxyl, kuhlanganise namaqembu e-hydroxyl eringini yayo enamakha.
(2). Ukungathathi hlangothi kwama-radicals mahhala
Ama-radicals wamahhala angama-molecule angazinzile afuna ama-electron kwamanye ama-molecule ukuze azinzise, okuholela ekulimaleni kwe-oxidative. Isakhiwo se-hydroxyl ku98% I-Fisetin Powderanganikela ngama-electron kuma-radicals mahhala, anciphise umsebenzi wawo, futhi ngaleyo ndlela anciphise ukulimala kwe-oxidative kumaseli.
(3). Ukususwa kwezinto ezisebenzayo ze-oxidizing
Njenge-antioxidant, i-Fisetin ingakwazi ukuqeda ama-oxidants asebenzayo njenge-superoxide anions, i-hydrogen peroxide, nama-hydroxyl radicals. Ngalo mphumela wokusula, i-Fisetin inganciphisa ukulimala kwamaselula okubangelwa ukucindezeleka okwenziwe nge-oxidative.
(4). Ukuvinjelwa komsebenzi we-oxidase
I-Fisetin ingaphinda ivimbele ukusebenza kwamanye ama-enzyme e-oxidase, njenge-peroxidase ne-oxidoreductase, ngaleyo ndlela yehlise ukuqhubeka kokusabela kwe-oxidative emzimbeni futhi yehlise izinga lokucindezeleka okwenziwe nge-oxidative.
(5). Thuthukisa umsebenzi we-enzyme ye-antioxidant
Ucwaningo luye lwabonisa ukuthi i-Fisetin ingakhuthaza imisebenzi ebalulekile ye-enzyme ye-antioxidant, njenge-superoxide dismutase (SOD) ne-glutathione peroxidase (GPx), ukusiza amangqamuzana abhekane ngokuphumelelayo nokucindezeleka okwenziwe nge-oxidative.
(6). Umphumela ophelele
Sekukonke, i-antioxidant mechanism yeInani eliphakeme kakhulu lama-Fisetinkuhlanganisa ukunikela ngama-electron ukuze kuncishiswe ama-radicals mahhala, ukusula ama-oxidant asebenzayo, ukuvimbela umsebenzi we-oxidase, nokukhuthaza umsebenzi we-enzyme ye-antioxidant, phakathi kwezinye izindlela, ukwenza ngokuhlanganyela imiphumela ye-antioxidant nokuvikela amangqamuzana emonakalweni we-oxidative.
2. Umphumela wokulwa nokuvuvukala we-Fisetin
I-Fisetin nayo ibhekwa njengemiphumela ebalulekile yokulwa nokuvuvukala, esiza ekudambiseni ukusabela kokuvuvukala.
(1). Ukulawula izindlela zokubonisa ukuvuvukala
I-Fisetin inemiphumela yokulwa nokuvuvukala ngokuthinta umsebenzi wezindlela eziningi zokubonisa ukuvuvukala. Ingakwazi ukulungisa i-NF- κ B. MAPK kanye ne-STAT yokubonisa izindlela kuvimbela ukubonakaliswa kwezakhi zofuzo ezihlobene nokuvuvukala, ngaleyo ndlela kunciphise ukuvela nokuphikelela kokusabela kokuvuvukala.
(2). Ukuvimbela ukukhululwa kwabalamuli abavuvukalayo
Ucwaningo luye lwabonisa lokhoI-Fisetin Powder ehlanzekileingavimbela ukukhululwa kwabalamuli abavuvukalayo, njenge-tumor necrosis factor- α (TNF)- α）、 Interleukin-1 β (IL-1) β） Kanye ne-interleukin-6 (IL-6), njll. Laba balamuli bokuvuvukala badlala indima ebalulekile ekuphenduleni kokuvuvukala, kanye nokuvinjelwa kwe-Fisetin kusiza ekudambiseni ubukhulu bokuvuvukala.
(3). Yehlisa ukusebenza kwamaseli avuthayo
I-Fisetin inganciphisa ukusebenza nokungena kwamangqamuzana okuvuvukala (njengama-macrophages, i-lymphocytes, ne-neutrophils), ukunciphisa izinga lapho amangqamuzana avuthayo akhulula khona abaxhumanisi abavuthayo, futhi ngaleyo ndlela anciphise ukulimala kwezicubu ezibangelwa ukusabela kokuvuvukala.
(4). Ukuvimbela ukubonakaliswa kwamaprotheni ahlobene nokuvuvukala
I-Fisetin ingase futhi ivimbele ukuvezwa kwamanye amaprotheni ahlobene nokuvuvukala, njenge-inducible nitric oxide synthase (iNOS) ne-cyclooxygenase-2 (COX-2), edlala indima ebalulekile enqubweni yokuvuvukala. Ngokuvimbela inkulumo yabo, i-Fisetin isiza ukulawula impendulo yokuvuvukala.
(5). Inhlanganisela ye-antioxidant ne-anti-inflammatory effects
Kuyaqapheleka ukuthi umphumela we-antioxidant we-Fisetin nawo unomthelela kumphumela wayo wokulwa nokuvuvukala. Izakhiwo ze-Antioxidant zinganciphisa umonakalo wokucindezelwa kwe-oxidative kumaseli, ngaleyo ndlela kunciphise izici ezingathandeki zokusabela kokuvuvukala futhi kuqhubeke nokunciphisa izinga lokuvuvukala.
3. Ukuvikelwa kwesimiso sezinzwa
(1). Ukuvikelwa kwe-Neuron
Ucwaningo luye lwabonisa lokhoI-Fisetin 98% ingakhuthaza ukukhula nokuthuthuka kwe-neuronal, futhi inomphumela wokuvikela kuma-neurons. Isiza ukugcina isimo esinempilo sama-neurons, ibambezeleka ukuwohloka kwe-neuronal, futhi inomphumela ovikelayo ohlelweni lwezinzwa.
(2). Ukulawulwa kwe-Neural conduction
Olunye ucwaningo lubonisa ukuthi i-Fisetin ingasiza ekuthuthukiseni ukusebenza kwe-nerve conduction, ikhuthaze ukukhululwa kwama-neurotransmitters kanye nokudluliselwa kwesignali yezinzwa, ngaleyo ndlela ithuthukise isimo sokusebenza kwesimiso sezinzwa.
(3). Ukulawulwa kwezakhi zofuzo ze-neuroprotective
I-Fisetin ingase ikhuthaze ukuvikelwa nokulungiswa kwesimiso sezinzwa ngokulawula ukuvezwa kwezakhi zofuzo ezithile ze-neuroprotective, njenge-BDNF (i-brain derived neurotrophic factor).
Ukuphepha kokudla kwansuku zonke kwe-Fisetin
(1). Ucwaningo lokuhlola izilwane
Ukuhlolwa kwezilwane kubonise ukuthi ukudla okusesilinganisweni kwe-Fisetin ngokuvamile kuphephile futhi akukho miphumela emibi enobuthi ebalulekile etholakele. Kodwa-ke, kufanele kuqashelwe ukuthi imiphumela yokuhlolwa kwezilwane ayikwazi ukwenziwa ngokuqondile kubantu.
(2). Umthamo kanye nokwehluka komuntu ngamunye
Ukusabela komuntu ngamunye ku-Fisetin kungase kuhluke, futhi kuyanconywa ukuthi ulandele umthamo onconyiwe womkhiqizi lapho uphuza i-Fisetin futhi uqaphe ngokucophelela ukusabela komzimba ngamunye.
Nakuba i-Fisetin inezinzuzo eziningi zezempilo ezingase zibe khona, ucwaningo olwengeziwe lwesayensi luyadingeka ukusekela ukuphepha kokudla kwansuku zonke kwe-Fisetin. Abathengi kufanele bacabangele ngokucophelela ukudla kwabo kwansuku zonke kwe-Fisetin futhi benze izinqumo ngokusekelwe ezimweni zabo. Kunconywa ukusebenzisa i-Fisetin ngaphansi kokuqondisa kukadokotela ukuze kuqinisekiswe ukuphepha nokusebenza kahle.
I-Xi'an tgybio Biotech Co., Ltd ingumkhiqizi we-fisetin powder, singahlinzekaamaphilisi e-fisetinnomaama-fisetin supplements , sinethimba elichwepheshile lokukusiza ukuthi udizayine ukupakisha namalebula, okuhlanganisa ukupakisha okungokwezifiso namalebula. Iwebhusayithi yethu /. Uma uthanda, ungathumela i-imeyili ku-rebecca@tgybio.com noma ku-WhatsAPP +86 18802932783.
Isikhathi sokuthumela: Mar-19-2024
