Umgubo weFisetin yinto yendalo ye-flavonoid ekhoyo ngokubanzi kwiziqhamo kunye nemifuno. Njengemolekyuli enokubakho ye-bioactive, i-Fisetin iye yatsala ingqalelo ebanzi kuluntu lwezenzululwazi. Ubume bayo beekhemikhali buqukethe amaqela amaninzi e-hydroxyl, eyenza ibe neempawu ezintle ze-antioxidant. Uphando luye lwabonisa ukuba i-Fisetin inokusebenzisa umsebenzi we-biological ngokulawula iindlela ezininzi zokubonisa, ezichaphazela iinkqubo ezifana ne-cell cycle kunye ne-apoptosis. Nangona kunjalo, uphando olongezelelweyo luyafuneka kwi-bioavailability kunye ne-pharmacokinetics ye-Fisetin ukubonisa indlela yokusebenza emzimbeni womntu. Nangona kunjalo, umba wokuba ukuthathwa kweFisetin yonke imihla kukhuselekile kuye kwaqwalaselwa kakhulu. Eli nqaku liza kuphonononga ngokucwangcisiweyo ukhuseleko lokutya kweFisetin imihla ngemihla kwiimbono ezahlukeneyo.
Yintoni iFisetin?
I-Fisetin yimbumba ye-flavonoid yendalo, ephuma kudidi lwe-flavonoid compounds. Ikho kwizityalo ezininzi, ezinjengama-apile, amaqunube, iilamuni, kwaye iyafumaneka nasekutyeni okufana netswele kunye ne cucumber. Ukuthetha ngokwekhemikhali, iFisetin yiflavonoid enesakhiwo samakhonkco amabini e-benzene kunye ne-heterocycle enye, equlethe amaqela amaninzi e-hydroxyl. Ezi zakhiwo ze-hydroxyl zinika i-Fisetin ngeempawu ezibalaseleyo ze-antioxidant.
I-Fisetin iye yatsala ingqalelo ebanzi kuluntu lwezenzululwazi ngenxa yesakhiwo sayo esisodwa sekhemikhali kunye nomsebenzi webhayoloji. Uphando lubonise ukuba iFisetin inokuba neziphumo zolawulo kwiinkqubo zebhayoloji ezinje ngomjikelezo weseli kunye ne-apoptosis, ngelixa ikwanezinto ezithile zebhayoloji. Kwi-vivo, i-Fisetin inokusebenzisa imiphumo yayo ngokulawula iindlela ezininzi zokubonisa iimpawu, kodwa uphando olongezelelweyo malunga ne-bioavailability kunye ne-pharmacokinetics iyafuneka ukuveza indlela yokusebenza emzimbeni womntu. Ngokubanzi, njenge-compound yendalo, i-Fisetin inokwakheka kweekhemikhali ezikhethekileyo kunye nomsebenzi webhayoloji, kwaye indlela yokusebenza kwayo emzimbeni womntu ifanelwe uphando olongezelelweyo.
Iinzuzo zeFisetin Powder
1. Impembelelo ye-antioxidant yeFisetin
98% iFisetinyinkompawundi yendalo ye-flavonoid eneempawu ezibalaseleyo ze-antioxidant.
(1). Ubume bekhemikhali beFisetin
I-Fisetin yindalo ye-flavonoid yendalo kunye ne-molecular formula C ₁æ H ₁₀O ₆. Iqulethe izakhiwo ezininzi ze-hydroxyl, kuquka namaqela e-hydroxyl kwiringi yayo enevumba elimnandi.
(2). Ukungathathi hlangothi kweeradicals zasimahla
Ii-radicals zamahhala ziyi-molecule ezingazinzanga ezifuna ii-electron ezivela kwezinye iimolekyuli ukuze zizinzise, ezikhokelela kumonakalo we-oxidative. Ubume behydroxyl kwi98% iFisetin Powderbanokunikela ngee-electron kwi-radicals yamahhala, banciphise umsebenzi wabo, kwaye ngaloo ndlela banciphise umonakalo we-oxidative kwiiseli.
(3). Ukususwa kwezinto ezisebenzayo ze-oxidizing
Njenge-antioxidant, i-Fisetin inokuphelisa ii-oxidants ezisebenzayo ezifana ne-superoxide anions, i-hydrogen peroxide, kunye ne-hydroxyl radicals. Ngale mpembelelo yokucoca, iFisetin inokunciphisa umonakalo weselula obangelwa kuxinzelelo lwe-oxidative.
(4). Ukuvinjelwa komsebenzi we-oxidase
I-Fisetin inokuthintela umsebenzi wezinye i-oxidase enzymes, ezifana ne-peroxidase kunye ne-oxidoreductase, ngaloo ndlela inciphisa ukuqhubela phambili kweempendulo ze-oxidative emzimbeni kunye nokunciphisa iqondo loxinzelelo lwe-oxidative.
(5). Ukukhuthaza umsebenzi we-enzyme ye-antioxidant
Uphando luye lwabonisa ukuba i-Fisetin inokukhuthaza imisebenzi ebalulekileyo ye-antioxidant ye-enzyme, njenge-superoxide dismutase (SOD) kunye ne-glutathione peroxidase (GPx), ukunceda iiseli ngokufanelekileyo ukuhlangabezana noxinzelelo lwe-oxidative.
(6). Isiphumo esibanzi
Ngokubanzi, i-antioxidant mechanism yeFisetin isambukukubandakanya ukunikela ngee-electron ukuze kuthintele i-radicals yamahhala, ukucima i-oxidants esebenzayo, ukuvimbela umsebenzi we-oxidase, kunye nokukhuthaza umsebenzi we-enzyme ye-antioxidant, phakathi kwezinye iindlela, ukusebenzisana ngokubambisana nemiphumo ye-antioxidant kunye nokukhusela iiseli kumonakalo we-oxidative.
2. Umphumo wokuchasa ukuvuvukala kweFisetin
I-Fisetin nayo ithathwa njengemiphumo ebalulekileyo yokuchasana nokudumba, inceda ukunciphisa ukuvuvukala.
(1). Ukulawula iindlela zokubonisa ukuvuvukala
I-Fisetin yenza i-anti-inflammatory effects ngokuchaphazela umsebenzi weendlela ezininzi zokubonisa ukuvuvukala. Iyakwazi ukulungelelanisa i-NF- κ B. I-MAPK kunye ne-STAT yokubonisa iindlela zokuthintela ukubonakaliswa kwezakhi zofuzo ezinxulumene nokuvuvukala, ngaloo ndlela ukunciphisa ukwenzeka kunye nokuqhubekayo kokuphendula okuvuthayo.
(2). Ukuthintela ukukhululwa kwabalamli abavuthayo
Uphando luye lwabonisa ukubaUmgubo weFisetin ococekileyoinokuthintela ukukhululwa kwabalamli abavuthayo, njenge-tumor necrosis factor-α (TNF) - α) 、 Interleukin-1 β (IL-1) β) kunye ne-interleukin-6 (IL-6), njl. Aba balamli abavuthayo badlala i indima ebalulekileyo kwimpendulo yokuvuvukala, kunye nokuvinjelwa kweFisetin kunceda ukunciphisa ubunzima bokuvuvukala.
(3). Ukunciphisa ukusebenza kweeseli ezivuthayo
I-Fisetin inokunciphisa ukusebenza kunye nokungena kweeseli ezivuthayo (ezifana ne-macrophages, i-lymphocytes, kunye ne-neutrophils), ukunciphisa izinga apho iiseli ezivuthayo zikhupha abalamli abavuthayo, kwaye ngaloo ndlela banciphise umonakalo wezicubu ezibangelwa ukusabela okuvuthayo.
(4). Ukuthintela ukubonakaliswa kweeprotheni ezinxulumene nokuvuvukala
I-Fisetin inokuthintela ukubonakaliswa kwezinye iiprotheni ezinxulumene nokuvuvukala, ezifana ne-inducible nitric oxide synthase (iNOS) kunye ne-cyclooxygenase-2 (COX-2), edlala indima ebalulekileyo kwinkqubo yokuvuvukala. Ngokuthintela intetho yabo, iFisetin inceda ukulawula impendulo yokuvuvukala.
(5). Ukudibanisa i-antioxidant kunye ne-anti-inflammatory effects
Kuyafaneleka ukuba uqaphele ukuba i-antioxidant effect ye-Fisetin nayo inegalelo kwimpembelelo yayo yokuchasana nokuvuvukala. Iipropathi ze-Antioxidant zinokunciphisa umonakalo woxinzelelo lwe-oxidative kwiiseli, ngaloo ndlela zinciphisa izinto ezinokuthi zithintele ukusabela okuvuthayo kunye nokunciphisa ngakumbi iqondo lokudumba.
3. Ukukhuselwa kwenkqubo ye-nervous
(1). Ukhuseleko lwe-Neuron
Uphando luye lwabonisa ukubaFisetin 98% inokukhuthaza ukukhula kwe-neuronal kunye nophuhliso, kwaye inefuthe lokukhusela kwi-neurons. Inceda ukugcina imeko enempilo ye-neurons, ukulibaziseka kwe-neuronal degeneration, kwaye inefuthe elikhuselayo kwinkqubo ye-nervous.
(2). Ukulawulwa kwe-Neural conduction
Olunye uphando lubonisa ukuba i-Fisetin inokunceda ekuphuculeni i-nerve conduction function, ikhuthaze ukukhululwa kwee-neurotransmitters kunye ne-nerve signal transduction, ngaloo ndlela iphucula imeko yokusebenza kwenkqubo ye-nervous.
(3). Ukulawulwa kweejini ze-neuroprotective
I-Fisetin inokukhuthaza ukukhuselwa kunye nokulungiswa kwenkqubo ye-nervous ngokulawula ukubonakaliswa kwezinye iijene ze-neuroprotective, ezifana ne-BDNF (i-brain derived neurotrophic factor).
Ukhuseleko lokuthatha yonke imihla kweFisetin
(1). Uphando lovavanyo lwezilwanyana
Uvavanyo lwezilwanyana lubonise ukuba ukuthatha ngokulinganayo kweFisetin ngokuqhelekileyo kukhuselekile kwaye akukho miphumo ebalulekileyo yetyhefu efunyenweyo. Noko ke, kufanele kuphawulwe ukuba iziphumo zovavanyo lwezilwanyana azinakudluliselwa ngokuthe ngqo ebantwini.
(2). Ithamo kunye nokwahlukana komntu ngamnye
Ukusabela komntu ngamnye kwi-Fisetin kunokwahluka, kwaye kuyacetyiswa ukuba ulandele idosi ecetyiswayo yomenzi xa ufaka i-Fisetin kwaye ubeke iliso elibukhali ukuphendula komzimba ngamnye.
Nangona i-Fisetin ineenzuzo ezininzi zezempilo, uphando olungakumbi lwezenzululwazi lufunekayo ukuxhasa ukhuseleko lokuthatha imihla ngemihla yeFisetin. Abathengi kufuneka baqwalasele ngokucokisekileyo ukutya kwabo kwansuku zonke kweFisetin kwaye benze izigqibo ezisekelwe kwiimeko zabo. Kunconywa ukusebenzisa i-Fisetin phantsi kwesikhokelo sogqirha wokubonisana nokuqinisekisa ukhuseleko kunye nokusebenza kakuhle.
I-Xi'an tgybio Biotech Co., Ltd ngumenzi we-fisetin powder, sinokubonelelai-fisetin capsulesokanyeizongezo zefisetin , sineqela lobuchwephesha lokukunceda uyile ukupakishwa kunye neelebhile, kubandakanya ukupakishwa okulungiselelweyo kunye neelebhile. Iwebhusayithi yethu ngu /. Ukuba unomdla, ungathumela i-imeyile ku rebecca@tgybio.com okanye WhatsAPP +86 18802932783.
Ixesha lokuposa: Mar-19-2024
