Ifu ya Fisetin ni flavonoide isanzwe iboneka cyane mu mbuto n'imboga. Nka molekile ishobora kuba bioaktike, Fisetin yakunze abantu benshi mubumenyi. Imiterere yimiti irimo amatsinda menshi ya hydroxyl, bigatuma agira antioxydeant nziza. Ubushakashatsi bwerekanye ko Fisetin ishobora gukora ibikorwa byibinyabuzima muguhuza inzira nyinshi zerekana ibimenyetso, bigira ingaruka kumasemburo ya selile na apoptose. Nyamara, ubushakashatsi buracyakenewe kuri bioavailable na pharmacokinetics ya Fisetin kugirango hagaragazwe uburyo bwibikorwa byumubiri wumuntu. Ariko, ikibazo cyo kumenya niba gufata buri munsi Fisetin ari umutekano byitabiriwe cyane. Iyi ngingo izasesengura gahunda yumutekano wo gufata buri munsi Fisetin muburyo butandukanye.
Fisetin ni iki
Fisetin ni ibimera bisanzwe bya flavonoide, biri mubyiciro bya flavonoide. Ibaho mu bimera byinshi, nka pome, strawberry, indimu, kandi wasangaga no mu biribwa nk'ibitunguru n'imbuto. Mu buryo bwa shimi, Fisetin ni flavonoide ifite imiterere yimpeta ebyiri za benzene hamwe na heterocycle imwe, irimo amatsinda menshi ya hydroxyl. Izi hydroxyl zubaka Fisetin hamwe na antioxydeant nziza cyane.
Fisetin yakunze abantu benshi mubumenyi bwa siyanse kubera imiterere yihariye yimiti nibikorwa byibinyabuzima. Ubushakashatsi bwerekanye ko Fisetin ishobora kugira ingaruka ku mikorere y’ibinyabuzima nka cycle selile na apoptose, mu gihe ifite n'ibikorwa bimwe na bimwe by’ibinyabuzima. Muri vivo, Fisetin irashobora gukoresha ingaruka zayo muguhuza inzira nyinshi zerekana ibimenyetso, ariko hakenewe ubundi bushakashatsi kubijyanye na bioavailable na pharmacokinetics kugirango hagaragazwe uburyo bwibikorwa mumubiri wumuntu. Muri rusange, nkibintu bisanzwe, Fisetin ifite imiterere yihariye yimiti nibikorwa byibinyabuzima, kandi uburyo bwibikorwa byumubiri wumuntu bukwiye ubushakashatsi.
Ifu ya Fisetin
1. Ingaruka ya antioxydeant ya Fisetin
98% Fisetinni flavonoide isanzwe hamwe nibintu byiza birwanya antioxydeant.
(1). Imiterere yimiti ya Fisetin
Fisetine ni flavonoide isanzwe hamwe na molekuline C ₁æ H ₁₀O ₆. Irimo hydroxyl yuburyo bwinshi, harimo amatsinda ya hydroxyl kumpeta yayo ya aromatic.
(2). Gutesha agaciro radicals yubuntu
Radikal yubusa ni molekile idahindagurika ishakisha electroni zindi molekile kugirango zihamye, biganisha ku kwangiza okiside. Imiterere ya hydroxyl muri98% Ifu ya FisetinIrashobora gutanga electron kuri radicals yubuntu, gutesha agaciro ibikorwa byayo, bityo bikagabanya kwangiza okiside kuri selile.
(3). Kurandura ibintu bikora okiside
Nka antioxydeant, Fisetin irashobora gukuraho okiside ikora nka anion ya superoxide, hydrogen peroxide, na hydroxyl radicals. Binyuze muri iyi ngaruka, Fisetin irashobora kugabanya ibyangiritse biterwa na stress ya okiside.
(4). Kubuza ibikorwa bya okiside
Fisetin irashobora kandi guhagarika ibikorwa bya enzymes zimwe na zimwe za okiside, nka peroxidase na oxydeductase, bityo bikagabanya iterambere ryimikorere ya okiside mu mubiri kandi bikagabanya urugero rwimyitwarire ya okiside.
(5). Teza imbere ibikorwa bya antioxydeant
Ubushakashatsi bwerekanye ko Fisetin ishobora guteza imbere ibikorwa bya enzyme ya antioxydeant nka superoxide dismutase (SOD) na glutathione peroxidase (GPx), kugirango ifashe selile guhangana neza na stress ya okiside.
(6). Ingaruka yuzuye
Muri rusange, uburyo bwa antioxydeant yaFisetinikubiyemo gutanga electron kugirango zanduze radicals yubuntu, gukuraho okiside ikora, guhagarika ibikorwa bya okiside, no guteza imbere ibikorwa bya enzyme ya antioxydeant, hamwe nubundi buryo, kugirango dufatanye gukora antioxydants no kurinda selile kwangirika kwa okiside.
2. Ingaruka zo kurwanya inflammatory Fisetin
Fisetin nayo ifatwa nkigifite ingaruka zikomeye zo kurwanya inflammatory, ifasha kugabanya ingaruka ziterwa no gutwika.
(1). Kugenzura inzira yerekana ibimenyetso
Fisetin igira ingaruka zo kurwanya inflammatory bigira ingaruka kumikorere yinzira nyinshi zerekana ibimenyetso. Irashobora guhindura NF- κ B. MAPK na STAT inzira yerekana inzira ibuza kwerekana genes zijyanye no gutwika, bityo bikagabanya kubaho no gukomeza kubaho kwifata.
(2). Kubuza kurekura abunzi batera umuriro
Ubushakashatsi bwerekanye koIfu nziza ya FisetinIrashobora kubuza kurekura abunzi batera umuriro, nkibibyimba bya niyose- α (TNF) - α） 、 Interleukin-1 β (IL-1) β） Na interleukin-6 (IL-6), nibindi. uruhare runini mugusubiza umuriro, no kubuza Fisetin bifasha kugabanya ubukana bwumuriro.
(3). Mugabanye gukora ingirabuzimafatizo
Fisetin irashobora kugabanya gukora no kwinjira mu ngirabuzimafatizo (nka macrophage, lymphocytes, na neutrophile), bikagabanya urugero ingirabuzimafatizo zirekura abunzi, bityo bikagabanya kwangirika kw'imitsi iterwa no gutwika ibintu.
(4). Kubuza kwerekana poroteyine zijyanye no gutwika
Fisetin irashobora kandi kubuza kwerekana poroteyine zimwe na zimwe zijyanye no gutwika, nka synthase ya nitric oxyde ya nitric (iNOS) na cyclooxygenase-2 (COX-2), bigira uruhare runini mugutwika. Muguhagarika imvugo yabo, Fisetin ifasha kugenzura igisubizo kibabaza.
(5). Gukomatanya ingaruka za antioxydeant na anti-inflammatory
Birakwiye ko tumenya ko antioxydeant ya Fisetin nayo igira uruhare mukurwanya anti-inflammatory. Indwara ya Antioxydeant irashobora kugabanya kwangirika kwingirabuzimafatizo ya selile, bityo bikagabanya ibintu bidashoboka byerekana ingaruka ziterwa no gutwika kandi bikagabanya urugero rwumuriro.
3. Kurinda sisitemu y'imitsi
(1). Kurinda Neuron
Ubushakashatsi bwerekanye koFisetin 98% Irashobora guteza imbere imikurire niterambere, kandi igira ingaruka zo kurinda neuron. Ifasha kubungabunga ubuzima bwiza bwa neuron, gutinda kwangirika kwa neuronal, kandi bigira ingaruka zo kurinda sisitemu y'imitsi.
(2). Amabwiriza agenga imiyoboro
Ubushakashatsi bumwe bwerekana ko Fisetin ishobora gufasha kunoza imikorere yimitsi itwara imitsi, guteza imbere irekurwa rya neurotransmitter hamwe nogukwirakwiza ibimenyetso byimyakura, bityo bikazamura imikorere yimikorere ya sisitemu.
(3). Kugena ingirabuzimafatizo
Fisetin irashobora guteza imbere kurinda no gusana sisitemu yimitsi igenga imiterere ya genes zimwe na zimwe zifata ubwonko, nka BDNF (ubwonko bukomoka kuri neurotrophique).
Umutekano wo gufata buri munsi Fisetin
(1). Ubushakashatsi bw'inyamaswa
Ubushakashatsi bw’inyamaswa bwerekanye ko gufata Fisetin mu rugero bisanzwe ari umutekano kandi nta ngaruka mbi z’uburozi zabonetse. Ariko, twakagombye kumenya ko ibisubizo byubushakashatsi bwinyamaswa bidashobora guhuzwa nabantu muburyo butaziguye.
(2). Dose nibitandukaniro
Umuntu ku giti cye kuri Fisetin arashobora gutandukana, kandi birasabwa gukurikiza urugero rwakozwe nu ruganda mugihe unywa Fisetin kandi ugakurikiranira hafi uko umuntu yitwara.
Nubwo Fisetin ifite inyungu nyinshi zubuzima, harakenewe ubundi bushakashatsi bwa siyanse kugirango dushyigikire umutekano wo gufata buri munsi Fisetin. Abaguzi bagomba gutekereza neza kubyo bafata buri munsi Fisetin bagafata ibyemezo bakurikije ibihe byabo. Birasabwa gukoresha Fisetin iyobowe na muganga wubujyanama kugirango umutekano urusheho kugenda neza.
Xi'an tgybio Biotech Co, Ltd ni uruganda rukora ifu ya fisetin, dushobora gutangafisetin capsulescyangwainyongera ya fisetin , dufite itsinda ryumwuga kugirango tugufashe gushushanya ibipapuro hamwe nibirango, harimo gupakira ibicuruzwa hamwe na labels. Urubuga rwacu ni /. Niba ubishaka, urashobora kohereza e-imeri kuri rebecca@tgybio.com cyangwa WhatsAPP +86 18802932783.
Igihe cyo kohereza: Werurwe-19-2024
