Fisetin Powder ndi flavonoid yachilengedwe yomwe imapezeka kwambiri mu zipatso ndi ndiwo zamasamba. Monga molekyulu ya bioactive, Fisetin yakopa chidwi chambiri mu gulu la asayansi. Kapangidwe kake ka mankhwala kumakhala ndi magulu angapo a hydroxyl, zomwe zimapangitsa kuti azikhala ndi antioxidant katundu. Kafukufuku wasonyeza kuti Fisetin amatha kuchita zinthu zachilengedwe powongolera njira zingapo zolumikizirana, zomwe zimakhudza njira monga ma cell cycle ndi apoptosis. Komabe, kafukufuku wowonjezera akufunika pa bioavailability ndi pharmacokinetics ya Fisetin kuwulula momwe amagwirira ntchito mthupi la munthu. Komabe, nkhani yoti kudya kwa tsiku ndi tsiku kwa Fisetin ndikotetezeka kwalandira chidwi kwambiri. Nkhaniyi ifufuza mwadongosolo chitetezo cha tsiku ndi tsiku cha Fisetin mosiyanasiyana.
Kodi Fisetin ndi chiyani?
Fisetin ndi mankhwala achilengedwe a flavonoid, omwe ali m'gulu lamafuta a flavonoid. Zimapezeka muzomera zambiri, monga maapulo, sitiroberi, mandimu, ndipo zimapezekanso m’zakudya monga anyezi ndi nkhaka. Kunena mwamankhwala, Fisetin ndi flavonoid yokhala ndi mphete ziwiri za benzene ndi heterocycle imodzi, yokhala ndi magulu angapo a hydroxyl. Ma hydroxyl awa amapatsa Fisetin ndi antioxidant katundu.
Fisetin yakopa chidwi chambiri kuchokera ku gulu la asayansi chifukwa cha kapangidwe kake kapadera ka mankhwala komanso zochitika zamoyo. Kafukufuku wawonetsa kuti Fisetin ikhoza kukhala ndi zowongolera pazachilengedwe monga ma cell cycle ndi apoptosis, komanso kukhala ndi zochitika zina zamoyo. Mu vivo, Fisetin ikhoza kuwonetsa zotsatira zake poyang'anira njira zingapo zowonetsera, koma kufufuza kwina pa bioavailability yake ndi pharmacokinetics ikufunika kuti awulule momwe imagwirira ntchito m'thupi la munthu. Ponseponse, monga gawo lachilengedwe, Fisetin ali ndi mawonekedwe apadera amankhwala ndi zochitika zamoyo, ndipo momwe amagwirira ntchito m'thupi la munthu amayenera kufufuza kwina.
Ubwino wa Fisetin Powder
1. Mphamvu ya antioxidant ya Fisetin
98% Fisetinndi flavonoid yachilengedwe yokhala ndi antioxidant katundu.
(1). Kapangidwe kakemidwe ka Fisetin
Fisetin ndi flavonoid yachilengedwe yokhala ndi formula ya maselo C ₁æ H ₁₀O ₆. Lili ndi ma hydroxyl angapo, kuphatikiza magulu a hydroxyl pa mphete yake yonunkhira.
(2). Neutralizing ma free radicals
Ma radicals aulere ndi mamolekyu osakhazikika omwe amafunafuna ma elekitironi kuchokera ku mamolekyu ena kuti akhazikike, zomwe zimapangitsa kuwonongeka kwa okosijeni. Mapangidwe a hydroxyl mu98% Fisetin Powderamatha kupereka ma elekitironi kuti ma radicals aulere, achepetse ntchito zawo, motero amachepetsa kuwonongeka kwa ma cell.
(3). Kuchotsa yogwira oxidizing zinthu
Monga antioxidant, Fisetin imatha kuchotsa ma oxidants omwe amagwira ntchito monga superoxide anions, hydrogen peroxide, ndi hydroxyl radicals. Pogwiritsa ntchito chilolezochi, Fisetin imatha kuchepetsa kuwonongeka kwa ma cell chifukwa cha kupsinjika kwa okosijeni.
(4). Kuletsa ntchito ya oxidase
Fisetin imathanso kulepheretsa ntchito ya ma enzyme ena oxidase, monga peroxidase ndi oxidoreductase, potero amachepetsa kupitilira kwa zomwe zimachitika mthupi komanso kuchepetsa kuchuluka kwa kupsinjika kwa okosijeni.
(5). Limbikitsani ntchito ya antioxidant enzyme
Kafukufuku wasonyeza kuti Fisetin ikhoza kulimbikitsa ntchito zofunikira za antioxidant enzyme, monga superoxide dismutase (SOD) ndi glutathione peroxidase (GPx), kuti athandize maselo kuti athe kuthana ndi vuto la okosijeni.
(6). Mwatsatanetsatane zotsatira
Ponseponse, njira ya antioxidant yaFisetin zambirikumaphatikizapo kupereka ma elekitironi kuti athetse ma radicals aulere, kuchotsa ma oxidants, kuletsa zochita za oxidase, ndi kulimbikitsa ntchito ya antioxidant enzyme, mwa njira zina, kuti agwiritse ntchito molumikizana antioxidant zotsatira ndikuteteza maselo ku kuwonongeka kwa okosijeni.
2. Mphamvu yotsutsa-kutupa ya Fisetin
Fisetin amaonedwanso kuti ali ndi zotsatira zotsutsana ndi kutupa, zomwe zimathandiza kuchepetsa kutupa.
(1). Kuwongolera njira zowonetsera zotupa
Fisetin imakhala ndi zotsatira zotsutsana ndi kutupa mwa kukhudza ntchito ya njira zambiri zowonetsera zotupa. Ikhoza kusintha NF- κ B. MAPK ndi njira zowonetsera STAT zimalepheretsa kufotokoza kwa majini okhudzana ndi kutupa, motero kuchepetsa zochitika ndi kulimbikira kwa machitidwe otupa.
(2). Kuletsa kutulutsidwa kwa oyimira pakati otupa
Kafukufuku wasonyeza kutiUfa Woyera wa Fisetinimatha kuletsa kutulutsidwa kwa oyimira pakati otupa, monga chotupa necrosis factor- α (TNF)- α）、 Interleukin-1 β (IL-1) β） Ndipo interleukin-6 (IL-6), etc. Udindo wofunikira pakuyankha kotupa, komanso kuletsa kwa Fisetin kumathandizira kuchepetsa kuopsa kwa kutupa.
(3). Chepetsani kuyambitsa kwa maselo otupa
Fisetin imatha kuchepetsa kuyambitsa ndi kulowa kwa maselo otupa (monga macrophages, lymphocytes, neutrophils), kuchepetsa kuchuluka kwa maselo otupa omwe amamasula oyimira pakati, motero amachepetsa kuwonongeka kwa minofu chifukwa cha zotupa.
(4). Kulepheretsa kufotokoza kwa mapuloteni okhudzana ndi kutupa
Fisetin imathanso kulepheretsa kufotokoza kwa mapuloteni ena okhudzana ndi kutupa, monga inducible nitric oxide synthase (iNOS) ndi cyclooxygenase-2 (COX-2), yomwe imagwira ntchito yofunika kwambiri pa kutupa. Poletsa mafotokozedwe awo, Fisetin amathandizira kuwongolera kuyankha kotupa.
(5). Kuphatikiza kwa antioxidant ndi anti-inflammatory effects
Ndizofunikira kudziwa kuti antioxidant zotsatira za Fisetin zimathandiziranso kuti zitheke. Antioxidant katundu akhoza kuchepetsa kuwonongeka kwa okosijeni kupsyinjika kwa maselo, potero kuchepetsa inducible zinthu za kutupa zimachitikira ndi kuchepetsanso mlingo wa kutupa.
3. Chitetezo cha dongosolo lamanjenje
(1). Chitetezo cha neuron
Kafukufuku wasonyeza kutiFisetin 98% imatha kulimbikitsa kukula ndi chitukuko cha neuronal, ndipo imakhala ndi chitetezo pamanyuroni. Zimathandizira kukhala ndi thanzi labwino la ma neurons, kuchedwetsa kuwonongeka kwa neuronal, komanso kumateteza dongosolo lamanjenje.
(2). Neural conduction regulation
Kafukufuku wina akuwonetsa kuti Fisetin ikhoza kuthandizira kupititsa patsogolo kayendedwe ka mitsempha, kulimbikitsa kutulutsidwa kwa ma neurotransmitters ndi kutulutsa chizindikiro cha minyewa, potero kuwongolera magwiridwe antchito a dongosolo lamanjenje.
(3). Kuwongolera kwa majini a neuroprotective
Fisetin ikhoza kulimbikitsa chitetezo ndi kukonzanso dongosolo la mitsempha mwa kuwongolera kufotokozera kwa majini ena oteteza ubongo, monga BDNF (brain derived neurotrophic factor).
Chitetezo cha tsiku ndi tsiku cha Fisetin
(1). Kafukufuku woyeserera nyama
Zoyeserera zanyama zawonetsa kuti kudya pang'ono kwa Fisetin nthawi zambiri kumakhala kotetezeka ndipo palibe zotsatirapo zoyipa zomwe zapezeka. Komabe, ziyenera kuzindikirika kuti zotsatira za kuyesa kwa nyama sizingasinthidwe mwachindunji kwa anthu.
(2). Mlingo ndi kusiyana payekha
Zomwe munthu amachita pa Fisetin zitha kukhala zosiyanasiyana, ndipo tikulimbikitsidwa kutsatira mlingo womwe wopanga amalimbikitsa mukamamwa Fisetin ndikuwunika momwe thupi limayendera.
Ngakhale kuti Fisetin ali ndi ubwino wambiri wathanzi, kafukufuku wambiri wa sayansi amafunika kuti athandizire chitetezo cha tsiku ndi tsiku cha Fisetin. Ogula ayenera kuganizira mozama momwe amadyera tsiku ndi tsiku Fisetin ndikupanga zisankho motengera momwe zinthu ziliri. Ndibwino kuti mugwiritse ntchito Fisetin motsogozedwa ndi dokotala kuti mutsimikizire chitetezo ndi mphamvu.
Xi'an tgybio Biotech Co., Ltd ndi wopanga ufa wa fisetin, titha kuperekakapisozi fisetinkapenafisetin zowonjezera , tili ndi gulu la akatswiri kuti likuthandizeni kupanga ma CD ndi zilembo, kuphatikiza ma CD ndi zilembo. Webusayiti yathu ndi /. Ngati mukufuna, mutha kutumiza imelo ku rebecca@tgybio.com kapena WhatsApp +86 18802932783.
Nthawi yotumiza: Mar-19-2024
