Ubonelelo ngokutya kwiBanga lezongezo zeSondlo Alpha-Ketoglutaric acid/2-Ketoglutaric acid

1.I-alpha ketoglutaric acid esetyenziswa njengomjikelezo we-tricarboxylic acid

I-α-Ketoglutarate yinto ebalulekileyo ye-metabolic intermediate kumjikelezo we-microbial tricarboxylic acid, eyona node engundoqo edibanisa i-carbon nitrogen metabolism kwiiseli. Ifumaneka emva kwe-isocitric acid nangaphambi kwe-succinyl coenzyme A kumjikelo. Kule nxalenye, i-anaplerotic reaction inokuveliswa nge-Transamination ye-glutamic acid α- Injongo yokuncedisa le metabolite ephakathi kunye ne-ketoglutaric acid nayo inokufezekiswa ngesenzo se-glutamate dehydrogenase kwi-glutamate.

2. alpha-i-ketoglutaric acid esetyenziselwa ukuvelisa ii-amino acids

I-asidi ye-Glutamic inokuvelisa i-glutamine phantsi kwesenzo se-glutamine synthase, esebenzisa i-molecule ye-ATP ukuvelisa i-glutamine phosphate; Le mveliso ephakathi ihlaselwa yi-ammonia njenge-nucleophilic reagent, ebangela ukubunjwa kwe-glutamine kunye ne-phosphate ye-inorganic.
3. i-alpha ketoglutaric acid esetyenziselwa izongezo zokutya
α- Ketoglutaric acid ithengiswa njengesongezo sokutya phantsi kwegama lokurhweba i-AKG okanye i-KG kwaye ithengiselwa abathandi bokuqina komzimba okanye abakhi bomzimba. Umthengisi uthi le nto inokuphucula ukusebenza kwincopho yoqeqesho. Umthengisi uthi oku kusekelwe "kuphando olubonisa ukuba i-ammonia eninzi inokubophelela kwi-α- Ketoglutaric acid ithathwa ukunciphisa iingxaki ezininzi ezibangelwa yityhefu ye-ammonia. Nangona kunjalo, kubonise ukuba i-α- Isifundo esisebenzayo kuphela kwi-ketoglutarate ekunciphiseni i-ammonia. ityhefu yenzelwe kuphela izigulane eziye zenziwa i-hemodialysis.