Tanga Ibiryo Byuzuye Ibiryo Byuzuye Alpha-Ketoglutaric aside / 2-Acide ya Ketoglutaric

1.alpha ketoglutaric aside ikoreshwa nka cycle ya tricarboxylic

α- Ketoglutarate ni intera ikomeye ya metabolike hagati ya mikorobe ya tricarboxylic acide ya mikorobe, ikaba ari urufunguzo rw'ingenzi ruhuza karubone ya azote metabolism mu ngirabuzimafatizo. Iherereye nyuma ya acide isocitric na mbere ya succinyl coenzyme A mukuzunguruka. Muri iki gice, reaction ya anaplerotique irashobora kubyara binyuze muri Transamination ya glutamic acide α- Intego yo kuzuza iyi metabolite hagati na aside ya ketoglutarike irashobora kandi kugerwaho hifashishijwe ibikorwa bya glutamate dehydrogenase kuri glutamate.

2. alpha-aside ya ketoglutarike ikoreshwa mu kubyara aside amine

Acide Glutamic irashobora kubyara glutamine munsi ya synthase ya glutamine, ikoresha molekile ya ATP kugirango ikore glutamine fosifate; Iki gicuruzwa giciriritse cyibasiwe na ammonia nka nucleophilique reagent, bigatuma habaho glutamine na fosifike idasanzwe.
3. alpha ketoglutaric aside ikoreshwa mubyokurya
α- Acide ya Ketoglutarike igurishwa nkinyongera yimirire mwizina ryubucuruzi AKG cyangwa a-KG kandi igurishwa kubakunda imyitozo ngororamubiri cyangwa abubaka umubiri. Umugurisha avuga ko iyi ngingo ishobora kunoza imikorere mugihe cyo guhugura. Umugurisha avuga ko ibyo bishingiye ku "bushakashatsi bwerekana ko ammonia ikabije ishobora guhuza α- Ketoglutaric aside ikurwaho kugira ngo igabanye ibibazo byinshi biterwa n'uburozi bwa amoniya. Icyakora, yerekanye ko α- Ubushakashatsi bwonyine bufatika kuri ketoglutarate mu kugabanya amoniya uburozi ni ubw'abarwayi batewe na hemodialyse.