Kedu ihe bụ uru nke ịṅụ L-carnitine?

L-Carnitine ntụ ntụ , dị ka ihe mgbakwunye nri na-edozi ahụ, anatawo nlebara anya dị ukwuu na ngalaba ahụike na mgbatị ahụ. A na-ewere ya na ọ nwere ọtụtụ uru ndị nwere ike ịnweta, sitere na inye ume, ịkwalite ịbelata ibu, iji kwado ahụike zuru oke. Edemede a ga-enyocha uru nke L-Carnitine n'ụzọ zuru ezu iji nyere gị aka ịghọta ọrụ ya wee nye gị ntọala mkpebi dabere na nyocha sayensị.

Nkọwa 1.L-Carnitine

1.1 Nkọwa na usoro ọrụ nke L-Carnitine

L-Carnitine bụ amino acid na-abụghị ihe dị mkpa nke imeju na akụrụ na-emepụta n'ime ya, a pụkwara inweta ya site na nri. Isi ọrụ ya bụ inyere abụba abụba aka ịbanye mitochondria site na akpụkpọ ahụ mitochondrial maka mmebi oxidative, si otú ahụ na-emepụta ume ma na-akwalite metabolism nkịtị nke sel ahụ.

Kpọmkwem, usoro ọrụ nke L-Carnitine gụnyere akụkụ ndị a:

1. Ụgbọ njem nke fatty acids: L-Carnitine nwere ike jikọta ya na fatty acids iji mepụta ogige L-Carnitine fatty acid, nke na-enyere aka na abụba abụba na-agafe n'ime na mpụta nke mitochondria site na Carnitine transferases wee banye n'ime ime mitochondria β Oxidative mmebi na-emepụta ATP. ike. A na-akpọ usoro a mbufe fatty acid.
2. Ịkwalite mmepụta ume: Mmetụta nke L-Carnitine nwere ike ịbawanye ọrụ nke enzymes na mitochondria, mee ka mmebi oxidative nke fatty acids na mmepụta nke ike ATP, si otú ahụ na-eme ka ike nke anụ ahụ dịkwuo elu.
3. Mbelata mkpokọta lactate: Ojiji L-Carnitine nwere ike belata mkpokọta lactate, nke bara uru maka ịgbatị ogologo oge na ike nke mmega ahụ ntachi obi.
4. Nkwado maka ahụike obi: L-Carnitine nwere ike imeziwanye ojiji nke fatty acids site na myocardium, na-akwalite ume metabolism na ọrụ nke akwara obi, ma si otú a gbochie omume nke ọrịa obi.

1.2 Isi mmalite na ụdị mgbakwunye

L-carnitine ntụ ntụ dị ọcha enwere ike nweta site na nri dị iche iche, gụnyere anụ, azụ, ngwaahịa mmiri ara ehi, na agwa. Nri sitere n'anụmanụ dịka anụ uhie, imeju beef, na anụ ezi nwere ọdịnaya dị elu, ebe nri ndị sitere na osisi dịka agwa soy, cheese, ahụekere, na almọnd nwere obere ọdịnaya.

Na mgbakwunye na nri nri, L-Carnitine nwekwara ike ịgbakwunye ya site na mgbakwunye ọnụ. Ụdị mgbakwunye a na-ahụkarị gụnyere:

1. L-Carnitine hydrochloride: Nke a bụ ụdị mgbakwunye a na-ahụkarị, na-apụtakarị na ntụ ntụ ma ọ bụ capsule, dị mfe ilo na mgbari.
2. Acetyl-L-Carnitine: Ụdị a nwere ike ịgafe ihe mgbochi ụbụrụ ọbara, na-akwado ahụike ụbụrụ na ọrụ ọgụgụ isi.
3. L-Carnitine L-Tartrate: Ụdị a dabara adaba maka ịkwalite arụmọrụ egwuregwu yana ịkwalite mgbake ahụ.

2.Nye ike ma melite arụmọrụ egwuregwu

2.1 Fatty acid metabolism na mmepụta ume

1. Na-akwalite mbufe fatty acid: L-Carnitine na-ejikọta ya na fatty acids iji mepụta ogige, na-enyere aka fatty acids banye n'ime mitochondrial membrane wee banye mitochondria maka mmebi oxidative, na-emepụta ike.
2. Ịkwalite mmepụta ume: L-Carnitine na-abawanye ọrụ nke enzymes na mitochondria, na-eme ka mmebi oxidative nke fatty acids na mmepụta nke ike ATP, si otú ahụ na-eme ka ike nke anụ ahụ dịkwuo elu.
3. Mbelata mkpokọta lactate: Ojiji L-Carnitine nwere ike belata mkpokọta lactate, nke bara uru maka ịgbatị ogologo oge na ike nke mmega ahụ ntachi obi.
4. Nkwado maka ahụike obi: L-Carnitine na-eme ka ojiji nke acid fatty na-eme ihe site na myocardium, na-akwalite ume metabolism na ọrụ nke akwara obi, ma na-egbochi omume nke ọrịa obi.

2.2L-Carnitine nnukwu ntụ ntụnwere mmetụta nke igbu oge ike ọgwụgwụ na imeziwanye ntachi obi.

2.3 L-Carnitine na-enyere aka ịkwalite mgbake na nrụzi ahụ, belata ike ọgwụgwụ anụ ahụ, melite arụmọrụ mmega ahụ, na ịkwalite ọrụ ahụ.

3.Promote arọ ọnwụ na abụba oxidation

3.1 Fatty acid iga na oxidation usoro

L-carnitine bụ amino acid na-adịghị mkpa nke na-arụ ọrụ dị mkpa na metabolism fatty acid. Fatty acids bụ otu n'ime isi mmalite nke ike n'ime ahụ, mana ha enweghị ike ịbanye mitochondria ozugbo maka metabolism oxidative. L-carnitine na-akwalite njem na oxidation nke fatty acids, na-enyere aka ibuga ha site na cytoplasm na ime mitochondria, si otú a na-ekere òkè na oxidative metabolism nke ọdụdụ asịd.

Fatty acids jikọtara ya na L-carnitine na cytoplasm iji mepụta acylcarnitine fatty, nke na-abanye na mitochondria site na onye na-ebu acylcarnitine fatty (CPT). N'ime mitochondria, acylcarnitine fatty na-eji nwayọọ nwayọọ na-agbaji ma gbarie ya site n'omume nke fatty acid oxidase, na-emepụta ike maka ojiji cell.

L carnitine ntụ ntụ na-arụ ọrụ dị ka onye na-ebu na usoro a, na-akwalite njem na oxidative metabolism nke ọdụdụ asịd, si otú na-enyere aka ịnọgide na-enwe ike ọkọnọ na lipid metabolism itule na cell. Ya mere, a na-eji L-carnitine eme ihe n'ọtụtụ ebe n'ọhịa nke ihe oriri na-edozi ahụ na ahụike dị ka ihe mgbakwunye nri iji nyere aka n'ịchịkwa abụba metabolism na imeziwanye mmega ahụ.

3.2 Belata mkpokọta abụba ma mee ka abụba na-ere ọkụ

1. Nke mbu, L-carnitine nwere ike ịkwalite mbufe na oxidative metabolism nke fatty acids, na-ebuga ha site na cytoplasm gaa n'ime mitochondria, na-akwalite mbelata oxidative nke abụba na ibelata mkpokọta ha.
2. Nke abuo, L-carnitine nwekwara ike ịbawanye ọnụego oxidation nke fatty acids na mitochondria, melite arụmọrụ nke abụba, ma mee ka abụba na-esiwanye ike, si otú ahụ na-ebelata mkpokọta abụba.
3. Na mgbakwunye, L-carnitine nwekwara ike ịkwalite uto akwara na metabolism, mụbaa ojiji nke abụba, ma na-akwalitekwa abụba ọkụ.

4.Ịkwalite ọrụ ụbụrụ na mgbochi ịka nká

Nke mbụ, L-carnitine na-ekere òkè n'ịhazi neurotransmitter metabolism na neuroprotection na ụbụrụ. Ọ na-enyere aka ịnọgide na-arụ ọrụ nkịtị nke neurons, na-akwalite njikọ na ntọhapụ nke neurotransmitters, ma si otú ahụ na-enyere aka ịnọgide na-arụ ọrụ akwara na ụbụrụ nkịtị.

Nke abuo, L-carnitine nwekwara mmetụta antioxidant, na-enyere aka ikpochapụ free radicals ma belata mmebi nke ụbụrụ oxidative na ụbụrụ, si otú ahụ na-enyere aka ichebe ụbụrụ ụbụrụ site na mmebi oxidative.

Tụkwasị na nke ahụ, L-carnitine nwere ike ịkwalite mgbasa ọbara na ụbụrụ, mee ka ọbara na-enye ụbụrụ na nri na-edozi ahụ na ụbụrụ, ma nyere aka melite metabolism na ọrụ nke ụbụrụ.

Ụlọ ọrụ Xi'an tgybio Biotech Co.,LtdỤlọ ọrụ L-carnitine, ụlọ ọrụ anyị nwere ike inyeL-carnitine capsulesnaIhe mgbakwunye L-carnitine . Ụlọ ọrụ anyị nwekwara ike ịnye ọrụ OEM/ODM One-Stop, gụnyere ngwugwu ahaziri ahazi na akara. Ọ bụrụ na ị chọrọ ịmụtakwu, ị nwere ike izipu e-mailRebecca@tgybio.comma ọ bụ WhatsApp+8618802962783.

Kpọtụrụ anyị

Mmechi:

L-Carnitine, dị ka ihe mgbakwunye nri na-edozi ahụ, nwere uru dị iche iche nwere ike ime, gụnyere ịkwalite ume, ịkwalite oke ibu, ịkwado ahụike obi, ịkwalite ọrụ ụbụrụ, na ịkwado ahụike nke metabolic. Agbanyeghị, maka onye ọ bụla, nsonaazụ ya nwere ike ịdịgasị iche dabere na ndịiche n'otu n'otu. Tupu ị tụlee iji L-Carnitine, biko kpọtụrụ dọkịta ma ọ bụ ọkachamara ahụike ọkachamara maka ndụmọdụ.

Ntụaka:

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2. Fielding R, Riede L, Lugo JP, Bellamine A. l-Carnitine mgbakwunye na mgbake mgbe emechara ahụ. Ihe oriri. 2018 Maachị 13;10 (3):349 . doi: 10.3390/nu10030349. PMID: 29534496; PMCID: PMC5872767.
3. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. Mmetụta nke (L-) carnitine na ọnwụ dị arọ na ndị okenye: nyochaa nhazi na meta-analysis nke ule ndị a na-achịkwaghị achịkwa. Obes Mkpu. 2016 Ọkt; 17 (10): 970-6 . doi: 10.1111/obr.12436. Epub 2016 Jun 22. PMID: 27335245.
4. Ihe ndị sitere na Malaguarnera M. Carnitine: uru ụlọ ọgwụ. Ọrịa Gastroenterol. 2012 Maachị; 28 (2): 166-76 . doi: 10.1097/MOG.0b013e328350a4b0. PMID: 22234221.
5. Hoppel C, Theuretzbacher AK. L-carnitine na mgbochi nke abụọ nke ọrịa obi: nyochaa usoro na meta-analysis. Mayo Clin Proc. 2013 Nov; 88 (11): 544-51 . doi: 10.1016/j.mayocp.2013.03.020. Epub 2013 Sep 26. PMID: 24075555; PMCID: PMC4191597.