Artesunate yog ib qho tshuaj tua kab sai tiv thaiv Plasmodium falciparum nyob rau theem erythrocytic, uas muaj txiaj ntsig zoo. Nws tuaj yeem tswj tau tus mob malaria sai sai tom qab noj nws. Nws yog siv rau kev cawm ntawm malaria txaus ntshai xws li hom hlwb thiab hom icteric, nrog rau kev kho mob ntawm falciparum malaria.
Lub mechanism ntawm artesunate yog artemisinin. Nws thawj zaug ua rau cov khoom noj vesicle membrane, deg membrane thiab mitochondria ntawm Plasmodium. Qhov thib ob yog nuclear membrane thiab endoplasmic reticulum. Tsis tas li ntawd, nws kuj muaj qee yam cuam tshuam rau chromatin hauv lub nucleus. Vim tias cov khoom no ua ntej ua rau cov khoom noj npuas hauv daim nyias nyias, yog li thaiv cov khoom noj khoom haus, ua rau cov kab mob malaria sai sai tshaib plab ntawm cov amino acids, sai sai ua npuas autophagic, thiab txuas ntxiv tawm ntawm lub cev, poob ntau ntawm cytoplasm thiab tuag. .
Lub luag haujlwm ntawm Artesunate:
Artesunate yog ib qho tshuaj tiv thaiv kab mob. Nws yog ib qho dej-soluble hemisuccinate derivative ntawm dihydroartemisinin.
Artemisinin yog sesquiterpene lactone cais tawm ntawm Artemisia annua, tshuaj ntsuab uas ib txwm siv hauv Suav teb rau kev kho mob malaria.
Artesunate thiab nws cov nquag metabolite dihydroartemisinin yog cov ntshav muaj zog schizonticides, nquag tawm tsam lub nplhaib theem ntawm cov cab.
Artesunate yog qhov zoo tagnrho rau kev kho mob malaria hnyav, suav nrog cerebral malaria. Nws kuj tseem muaj zog tiv thaiv mefloquine resistant hom P. falciparum. Nws tsis ruaj khov hauv cov tshuaj nruab nrab thiab yog li ntawd tsuas yog muaj rau kev txhaj tshuaj raws li artesunic acid.
Daim ntawv thov
1. Siv rau hauv cov zaub mov, nws tau dhau los ua cov khoom siv tshiab uas siv rau hauv kev lag luam khoom noj thiab dej haus;
2. Siv rau hauv cov khoom noj qab haus huv, nws yog cov khoom noj qab haus huv los tswj kev pw tsaug zog;
3. Siv rau hauv kev lag luam tshuaj, muaj txiaj ntsig zoo ntawm kev kho kab mob siab.
Pom zoo cia:
Artemisinin raug pom zoo kom khaws cia rau hauv qhov chaw txias, qhuav, kaw los ntawm huab cua sab nraud. Peb xa cov khoom rau hauv ib lub hnab ntim ob lub hnab uas tuaj yeem rov ua dua. Lwm lub thawv yog pom zoo muab kaw los ntawm huab cua sab nraud.
Post lub sij hawm: Sep-27-2022
